This page tracks new and upcoming treatment options for type 1 diabetes (T1D). What’s in development? What’s promising? What’s available soon? Current topics include VX-880, SRI-37330, GDF15, and more.
Last updated: 3 years ago
News
- Stem cell-based treatment produces insulin in patients with Type 1 diabetes Dec 2, 2021
- Cure for Type 1 Diabetes? For One Man, It Seems to Have Worked: “A new treatment using stem cells that produce insulin has surprised experts and given them hope for the 1.5 million Americans living with the disease.” Nov 27, 2021
- A new therapy for treating Type 1 diabetes Oct 20, 2021
- Vertex Announces Positive Day 90 Data for the First Patient in the Phase 1/2 Clinical Trial Dosed With VX-880, a Novel Investigational Stem Cell-Derived Therapy for the Treatment of Type 1 Diabetes Oct 18, 2021
- Swapping alpha cells for beta cells to treat diabetes: Antibodies that convert glucagon-producing cells into insulin-producing ones cure mouse models of the disease Mar 1, 2021
- Study could offer a new way to treat Type 1 and Type 2 diabetes: Blocking cell receptors for glucagon, the counter-hormone to insulin, cured mouse models of diabetes Mar 1, 2021
- Novel drug candidate offers a major advance in the treatment for diabetes Jul 28, 2020
- Novel diabetes drug candidate shows promising properties in human islets and mouse models Jul 28, 2020
- Israeli firm says micro-pancreas to ‘cure’ diabetes ready for UK trials: hopes testing can begin in 2021 on product intended to free people of need for insulin injections Jul 23, 2020
- A discovery step toward cell replacement therapy for diabetes May 7, 2020
- Type 1 diabetes may be two conditions that need different treatments Mar 16, 2020
- Beta cell production increased by unique drug combination Feb 14, 2020
- JDRF Reaches New Milestones in Work to Drive Cures for Type 1 Diabetes and Improve Lives Feb 14, 2020
- vTv Therapeutics Announces Positive Results from Part 2 of the Phase 2 Simplici-T1 Study of TTP399, Potential First-in-Class Oral Adjunctive Therapy for Patients with Type 1 Diabetes Feb 10, 2020
- Type 1 diabetes could be tackled by a radical technique involving injecting insulin-producing cells into the eye Feb 4, 2020
- Cell research offers diabetes treatment hope Jan 17, 2020
- A new cell treatment to enhance islet transplantation could help maintain healthy blood sugar levels in Type 1 diabetes without the need for multiple transplants of insulin producing cells or regular insulin injections, research suggests Jan 17, 2020
- Islet protective factor GDF15 reduces development of type 1 diabetes in mice Jan 10, 2020
- Big Advances Made Against Diabetes in 2019 Dec 31, 2019
- FDA Approves Sanofi’s Toujeo to Treat Childhood Type 1 Diabetes Nov 27, 2019
- US companies celebrate 25-year commitment to curing type 1 diabetes Nov 21, 2019
- Technology is quickly changing how to treat patients, often kids, with type 1 diabetes Nov 18, 2019
- Diabetics make insulin for first time with stem cell-derived therapy Nov 10, 2019
- ‘Super-grafts’ that could treat diabetes Nov 6, 2019
- Sanofi: Positive results in Phase 3 trial for Toujeo® in children and adolescents with type 1 diabetes Nov 4, 2019
- Pandion and Astellas Announce Collaboration to Deliver Pancreas-Targeted Immunomodulators Oct 31, 2019
- Artificial pancreas system better controls blood glucose levels than current technology: safety, efficacy benefits for people with type 1 diabetes Oct 24, 2019
- Diabetes: a next-generation therapy soon available? Oct 16, 2019
- Ultrasound might become a new way to manage diabetes: This form of energy releases insulin in mice and might someday help control blood sugar in people Oct 1, 2019
- EASD 2019: Imcyse to present first-in-human phase 1b study results in type 1 diabetes Sep 25, 2019
- UVA Scientists Identify Potential Way to Prevent Type 1 Diabetes Sep 25, 2019
- Is the future of diabetes treatment better drugs or better care? Sep 23, 2019
- Vertex Pharmaceuticals announces acquisition of startup in bid to cure type 1 diabetes Sep 3, 2019
- Type 1 Diabetes Immunotherapy Shows Promise in Phase I Aug 28, 2019
- Discovery may point to better treatments for type 1 diabetes Aug 26, 2019
- Implanted ‘cell pouch’ could help Type 1 diabetics, researchers say Jul 3, 2019
- The little patches that can make managing diabetes a whole lot easier May 29, 2019
- ‘Smart’ insulin could prevent hypoglycemia during diabetes treatment May 16, 2019
- A new system for treating type 1 diabetes mellitus May 10, 2019
- New hope for stem cell approach to treating diabetes Jan 17, 2019
Research
- Insulin expression and C-peptide in type 1 diabetes subjects implanted with stem cell-derived pancreatic endoderm cells in an encapsulation device Dec 2, 2021
- Evolving Antibody Therapies for the Treatment of Type 1 Diabetes Feb 18, 2021
- Emerging Roles of Dipeptidyl Peptidase-4 Inhibitors in Delaying the Progression of Type 1 Diabetes Mellitus Feb 10, 2021
- Transforming type 1 diabetes: the next wave of innovation Feb 6, 2021
- Harnessing CD8(+) T-cell exhaustion to treat type 1 diabetes Feb 6, 2021
- Microencapsulation for the cell and molecular therapy of type 1 diabetes mellitus: actual state and future perspectives between promise and progress Jul 22, 2020
- C-peptide corrects hepatocellular dysfunction in a rat model of type 1 diabetes and could be used as an alternative therapy to insulin Jun 11, 2020
- Improved human islets’ viability and functionality with mesenchymal stem cells and arg-gly-asp tripeptides supplementation of alginate micro-encapsulated islets in vitro Jun 5, 2020
- Pre-clinical evaluation of TYK2 inhibitors for human beta cell protection in type 1 diabetes Jun 1, 2020
- Depletion of the diabetic gut microbiota resistance enhances stem cells therapy in type 1 diabetes mellitus: modulating gut microbiota may help to improve the effects of MSC transplantation for T1DM May 17, 2020
- A method for the generation of human stem cell-derived alpha cells May 7, 2020
- CD8+ regulatory T cells are critical in prevention of autoimmune-mediated diabetes Apr 22, 2020
- PD-1 and PD-L1 Expression in Peripheral CD4/CD8+ T Cells Is Restored in the Partial Remission Phase in Type 1 Diabetes Apr 1, 2020
- Remission of autoimmune diabetes by anti-TCR combination therapies with anti-IL-17A or/and anti-IL-6 in the IDDM rat model of type 1 diabetes. Feb 28, 2020
- Comprehensive Proteomics Analysis of Stressed Human Islets Identifies GDF15 as a Target for Type 1 Diabetes Intervention Jan 9, 2020
- Investigating curcumin potential for diabetes cell therapy, in vitro and in vivo study Dec 15, 2019
- Immunomodulation Followed By Antigen-Specific Treg Infusion Controls Islet Autoimmunity Nov 11, 2019
- Toward Automated Insulin Delivery Oct 31, 2019
- Advances in technology for management of type 1 diabetes Oct 5, 2019
- Generation of insulin-secreting cells from mouse gallbladder stem cells by small molecules in vitro Sep 23, 2019
- Automated Insulin Delivery: The Artificial Pancreas Technical Challenges Sep 19, 2019
- Effectiveness of intraperitoneal therapy of insulin-dependent diabetes mellitus in dogs using Neo-Islets (aggregates of adipose stem and pancreatic islet cells) Sep 19, 2019
- Inhibitory B cell co-receptors and autoimmune diseases Sep 18, 2019
- Advances in β-cell replacement therapy for the treatment of type 1 diabetes Sep 13, 2019
- The road from intermittently scanned continuous glucose monitoring to hybrid closed-loop systems Aug 30, 2019
- Novel epigenetic-sensitive clinical challenges both in type 1 and type 2 diabetes: Epigenetics played a relevant role in prevention, diagnosis, and treatment of diabetes Aug 19, 2019
- The neuroprotection of liraglutide on diabetic cognitive deficits is associated with improved hippocampal synapses and inhibited neuronal apoptosis Aug 15, 2019
- A Technological Revolution: The Integration of New Treatments to Manage Type 1 Diabetes Aug 1, 2019
- The remission phase in type 1 diabetes: highly valuable for studies aiming to identify possible targets that may be used to cure T1DM Jul 25, 2019
- L-serine: a neglected amino acid with a potential therapeutic role in diabetes Jul 25, 2019
- Tellurium Compounds Prevent and Reverse Type-1 Diabetes in NOD Mice by Modulating α4β7 Integrin Activity, IL-1β, and T Regulatory Cells May 29, 2019
- Use of sensor-integrated pump therapy to reduce hypoglycaemia in people with Type 1 diabetes May 27, 2019
- Complex dietary polysaccharide modulates gut immune function and microbiota, and promotes protection from autoimmune diabetes Feb 3, 2019
- Disease-Modifying Therapies in Type 1 Diabetes: A Look into the Future of Diabetes Practice Jan 5, 2019
- Targeting Type 1 Diabetes: Selective Approaches for New Therapies Jan 4, 2019
- Mesenchymal stem cells to treat type 1 diabetes Nov 30, 2018
- Biopsychosocial Factors Associated With Satisfaction and Sustained Use of Artificial Pancreas Technology and Its Components: a Call to the Technology Field Sep 26, 2018
- Will Genetic Engineering Carry Xenotransplantation of Pig Islets to the Clinic? Sep 18, 2018
- Therapies to Suppress β Cell Autoimmunity in Type 1 Diabetes Aug 16, 2018
- Carbamazepine, a beta-cell protecting drug, reduces type 1 diabetes incidence in NOD mice Mar 15, 2018
- The potential and challenges of alternative sources of β cells for the cure of type 1 diabetes Mar 1, 2018
Clinical Trials
- Device-Less Technique in Islet Transplantation Oct 11, 2021
- A Safety, Tolerability, and Efficacy Study of VX-880 in Participants With Type 1 Diabetes Mar 8, 2021
- Phase 2, Dose Ranging, Efficacy Study of Anti-thymocyte Globulin (ATG) Within 6 Weeks of Diagnosis of Type 1 Diabetes (T1D) Aug 12, 2020
- Islet Transplant in Patients With Type I Diabetes Jul 30, 2020
- Targeting Inflammation With Salsalate in Type 1 Diabetes Neuropathy Nov 28, 2019
- Cellular Therapy for Type 1 Diabetes Using Mesenchymal Stem Cells Sep 20, 2019
- Clinical Phase II/III Trial of Ustekinumab to Treat Type 1 Diabetes (UST1D2) Sep 14, 2019
- Effect of the SGLT-2 Inhibitor Dapagliflozin on IAH in Type 1 Diabetes Sep 13, 2019
- A Study of LY900014 in Participants With Type 1 Diabetes Mellitus Sep 4, 2019
- Interleukin-2 Therapy of Autoimmunity in Diabetes (ITAD) Sep 4, 2019
- Rituximab and Abatacept for Prevention or Reversal of Type 1 Diabetes (TN25) Aug 15, 2019
- A Safety, Tolerability and Efficacy Study of Sernova’s Cell Pouch™ for Clinical Islet Transplantation Jul 29, 2019
- Clinical Application of Stem Cell Educator Therapy in Type 1 Diabetes Jul 9, 2019
- Butyrate to Improve Insulin Sensitivity and Lower Triglycerides in Type 1 Diabetes Subjects Jul 3, 2019
- A Study to Look at How Safe NNC0268-0965 (insulin 965) is in Healthy People and People With Type 1 Diabetes Jun 11, 2019
- The Bihormonal iLet Bionic Pancreas Feasibility Study Jun 5, 2019
- Safety, Tolerability and Potential Efficacy of AVT001 in Patients With Type 1 Diabetes May 9, 2019
- Stem Cells From Human Exfoliated Teeth in Treatment of Diabetic Patients With Significantly Reduced Islet Function Apr 22, 2019
- Polyclonal Regulatory T Cell (PolyTreg) Immunotherapy in Islet Transplantation Apr 17, 2019
- Targeting Beta Cell Dysfunction With Liraglutide or Golimumab in Longstanding T1D Apr 15, 2019
- Triple Therapy for Type 1 Diabetes With Insulin, Semaglutide, and Dapagliflozin Apr 2, 2019
- MER3101: MAS-1 Adjuvanted Antigen-specific Immunotherapeutic for Prevention and Treatment of Type 1 Diabetes Dec 27, 2018
- A Study of Autologous Induced Islet Body With Type 1 Diabetes Nov 2, 2018
- Study Evaluating the Safety of Islet Transplant in Patients With Type I Diabetes Oct 9, 2018
